Over the last decade, the c‐myb gene and its protein product, Myb, have undergone extensive examination and manipulation in hemopoietic tissues. Although it is rarely disputed that, as a transcription factor, Myb regulates cell cycling, proliferation and differentiation, identification of genes directly controlled by Myb has been surprisingly difficult. More recently, genes with promoter regions that contain Myb recognition sequences have been identified, but a direct proliferative response to Myb via these ‘target genes’ has yet to be demonstrated. Mutagenesis studies (...) have defined domains of the protein which influence its transcriptional activity and transforming potential; however how the molecule interacts with itself and with other cellular factors is only beginning to be understood. A broader examination of c‐myb expression in normal and malignant tissues suggests an analogous role for Myb in proliferation, differentiation and transformation of nonhemopoietic tissues. (shrink)

Notice is given of the discovery of two reports and an accompanying manuscript map by Andrew Ramsay, on the geology of the St David's area, Pembrokeshire. This adds to previously published information on early geological work in this important region: Ramsay's report throw some light on his attitude towards Murchison's ideas on Welsh stratigraphy. The map is the earliest known version of the Survey's St David's sheet.

Commodity chain analysis (Bair and Ramsay, 2003 Multinational Companies and Global Human Resource Strategies) is used to explore where economic pressure (from consumers) or socio-political pressure (from governments and NGOs) can be applied to reduce worker exploitation. Six paths are illustrated with examples of successful and unsuccessful application of pressure. Three conclusions are reached :Economic pressure on companies and brand owners is more likely to lead to improved workplace conditions than socio-political pressure; Brand owners are more likely to implement (...) improved workplace conditions than retailers; and Retailers who are under extreme consumer price pressure will resist improving workplace conditions. (shrink)

First published in 1925. This book is a brief analysis of the historical relation of contemporary writers to their immediate predecessors. The author attempts to further a comprehensive summary of certain selected writers, with a criticism of their ideas, while in the last chapter an attempt is made at synthesis. Among those whose work is examined are Ramsay MacDonald, Bertrand Russell, Harold Laski, the Pauls, Hobhouse, Bryce, G. D. H. Cole, Norman Angell, etc. This title will be of great (...) interest to students of politics, philosophy and history. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Notes and Fragments RAILING AGAINST REALISM: PHILOSOPHY AND TO THE LIGHTHOUSE by S. P. ROSENBAUM The argument of Graheim Parkes's "Imagining Reality in To the Lighthouse" is described by its author as "a railing against the realist position" (p. 35) as he understands it primarily in my article "The Philosophical Reedism ofVirginia Woolf." ' Apart from the question of whemer railing is a useful way of conducting an inquiry (...) into literature and philosophy, Parkes's discussion raises several important issues about these connections. The way diey are raised, however, involves various mistedces and muddles that make a brief reply to his eurticle difficult. To begin with a small reveeding example, Parkes asserts that I miss the irony in Virginia Woolfs use of die letters P, Q, and R to describe Mr. Ramsay's problems of diought (p. 41). Here is what I wrote: "By representing Mr. Ramsay 's thinking as proceeding in die very genered form of conventional logical symbols, Virginia Woolf is wittily extending the standard letters used to symbolize die conditional type of argument, If P men Cf (p. 339, with italics added this time). Parkes's misreading of my text does not inspire confidence when he turns to Virginia Woolfs fiction or G. E. Moore's philosophy. On a more significant issue, Parkes complains that I boggle his mind by saying diat philosophically, Moore influenced Virginia Woolf more man anyone else, whereas Platonic ideas abound in her books (p. 35). Of course they do, but not very much in her epistemology, which was the subject of my eurticle.2 What Peirkes does not mention is that Plato was also a profound influence on Moore's philosophy. One of die reasons Moore's influence on Bloomsbury was so strong is that he reinterpreted Plato for them. In her images and ideas Virginia Woolf was influenced direcdy dirough her reading of Plato etnd also indirectly through the work of Plotinus and Moore. These influences are not easily sepeurated, which is why studies of Platonic emd Neoplatonic influences in her work that ignore Moore's significance are so incomplete. 89 90Philosophy and Literature Peirkes claims mat die evidence of Moore's influence on Virginia Woolf is slight (p. 34), and then he concerns himself with the putative influences of German philosophers for whom mere is no evidence at all. In the fifteen years since I wrote my article, the biographical evidence for Moore's influence has continued to accumulate as Virginia Woolfs letters, memoirs, emd dieiries were published. From her first novel, in which Principia Etnica is quoted emd briefly discussed, down to die recently discovered revised version of her last memoir, in which she reaffirms her deep respect for Moore,3 the indications of Moore's significance for Virginia Woolf ought to convince any disinterested reader. It cannot be dismissed with a sneer about "the voguish fascination of the Bloomsbury Group..." (p. 34), especially from someone proposing to study yet again the depth psychology of her fiction via Nietzsche and Heidegger (P- 44). Nothing I say here, of course, will persuade Parkes of the value of philosophical realism for understanding To the Lighthouse because diat philosophy, as he conceives of it in his article, consists of straw. To tedce just one exeimple, Peirkes appeeurs to believe Moore's epistemology etrgues "diat things and persons are what they are independently of human consciousness" (p. 37). There is no space here to explain philosophical realism again to Parkes, odier than to note that it is not inconsistent with the veirious concerns (to use Peurkes's terminology) about "transpersonal imagination" or "participation in phenomena" that he finds so interesting in the novel. But what about die novel? For readers indifferent to whether Moore or Russell, Nietzsche or Heidegger are to be found in To the Lighthouse, the relevant question is what such philosophical interpretations medce of it. To them I ceui only say, reread the novel and then ask yourselves if an account of it diat says nothing about die value of art and almost nodiing about the value oflove bears much resemblance to your reading experience. Parkes thinks the portrait of Mr. Ramsay is unsympathetic because he is criticized emd mocked... (shrink)

Fabvla misere mutila: this notice in the Oxford edition, reinforced in the critical apparatus, warns the reader against the transmitted text of the Heradidae. It tends to perpetuate the view which Wilamowitz, following up the hints of G. Hermann and A. Kirchhoff, propounded in 1882. The sweeping assurance of his famous article gave it a publicity which makes a detailed rehearsal superfluous. Wilamowitz throughout his life stuck to the opinion that ‘wir lesen die Herakliden in der Bearbeitung eines Regisseurs’. Dissentient (...) voices have been raised from time to time. M. Pohlenz in 1930 even proposed an interpretation of the Heradidae which quietly discarded the thesis of Wilamowitz. Nevertheless the latter appears still to hold the field at least in the English-speaking countries. If it is correct, the Heradidae of Euripides is beyond our reach. This conclusion has indeed, quite recently, been drawn by H. D. F. Kitto. (shrink)

A geometric formulation of the gravitation theory in the spacetime R × S 3 is given. A linear connection is introduced on the tangent bundle T(R × S 3 ) and then the connection coefficients and the Riemann curvature tensor are calculated. It is shown that their expressions differ from those of Carmeli and Malin [Found. Phys.17, 407 (1987)] by supplementary terms due to the noncommutativity of derivatives used on the spacetime R × S 3 . The Einstein field equations (...) are written as usually and a comparison with other results is given. Finally, some observations about a possible gauge theory of gravitation in the spacetime R × S 3 are made. (shrink)

Mathematical modeling is a convenient way for characterization of complex ecosystems. This approach was applied to study the dynamics of zooplankton in Lake Sevan (Armenia) at different stages of anthropogenic eutrophication with the use of a novel method called discrete modeling of dynamical systems with feedback (DMDS). Simulation demonstrated that the application of this method helps in characterization of inter- and intra-component relationships in a natural ecosystem. This method describes all possible pairwise inter-component relationships like “plus–plus,” “minus–minus,” “plus–minus,” “plus–zero,” “minus–zero,” (...) and “zero–zero” that occur in most ecosystems. Based on the results, a working hypothesis was formulated. It was found that the sensitivity to weak external influence in zooplanktons was the greatest during the mid period of eutrophication in Lake Sevan, whereas in the final stages of eutrophication, an outbreak in the biomass production of cyanobacteria was evident. To support this approach, a weak external disturbance in the form of magnetic storm was used to see its effect on species Daphnia longispina sevanica. A statistically significant correlation between the frequency of magnetic storms and the number of this species was revealed and an increase in the number of toxic cyanobacteria species as a consequence of eutrophication. This paper, for the first time, suggests a DMDS method, to diagnose impact of anthropogenic eutrophication on environment. (shrink)

Keine ausführliche Beschreibung für "Über das Wesen der Naturgesetze" verfügbar.

A lyrical variation on vv. 27–30, the present passage is, at the same time, a new version of Hec. 631–7. A comparison is instructive in various respects, but Hel. 27 f. will not be quoted in justification of what L gives in vv. 236 f. This wording raises the following objections: the last word, , is outside the metre and not easily attached to the following colon, the beginning of which naturally coincides with the new sentence and new idea If, (...) then, is obelized—and this seems unavoidable—the words. (shrink)

Due to its extraordinary predictive power and the great generality of its mathematical structure, quantum theory is able, at least in principle, to describe all the microscopic and macroscopic properties of the physical world, from the subatomic to the cosmological level. Nevertheless, ever since the Copen hagen and Gottingen schools in 1927 gave it the definitive formu lation, now commonly known as the orthodox interpretation, the theory has suffered from very serious logical and epistemologi cal problems. These shortcomings were immediately (...) pointed out by some of the principal founders themselves of quantum theory, to wit, Planck, Einstein, Ehrenfest, Schrodinger, and de Broglie, and by the philosopher Karl Popper, who assumed a position of radical criticism with regard to the standard formulation of the theory. The aim of the participants in the workshop on Open Questions in Quantum Physics, which was held in Bari (Italy), in the Department of Physics of the University, during May 1983 and whose Proceedings are collected in the present volume, accord ingly was to discuss the formal, the physical and the epistemo logical difficulties of quantum theory in the light of recent crucial developments and to propose some possible resolutions of three basic conceptual dilemmas, which are posed respectively ~: (a) the physical developments of the Einstein-Podolsky-Rosen argument and Bell's theorem, i. e. (shrink)

First published in 2002. Routledge is an imprint of Taylor & Francis, an informa company.